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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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E3 ubiquitin ligase E6AP negatively regulates adipogenesis by downregulating proadipogenic factor C/EBPalpha

Pooja Pal1, Savita Lochab, Jitendra Kumar Kanaujiya

  • 1LSS008, DTDD Division, CSIR-Central Drug Research Institute, Lucknow, India.

Plos One
|June 14, 2013
PubMed
Summary

E3 ubiquitin ligase E6AP inhibits adipocyte differentiation by degrading CCAAT/Enhancer Binding Protein Alpha (C/EBPα). Knocking down E6AP promotes adipogenesis, revealing E6AP

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