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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

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Related Experiment Video

Updated: May 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Primary cutaneous mantle cell lymphoma: a case report.

L D Mazzuoccolo1, G A Castro Perez, I Sorin

  • 1HIGA. Eva Perón, Gral San Martin, Buenos Aires, Argentina.

Case Reports in Dermatological Medicine
|June 14, 2013
PubMed
Summary

Primary cutaneous mantle cell lymphoma (MCL) is a rare skin cancer. This case highlights its clinical, pathological, and molecular features, aiding in diagnosis and understanding of this uncommon B-cell lymphoma.

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Last Updated: May 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous mantle cell lymphoma (MCL) is a rare skin malignancy.
  • It involves naive pregerminal CD-5 positive B cells without extracutaneous spread.
  • Cyclin D1 overexpression is a key diagnostic marker.

Purpose of the Study:

  • To present a comprehensive case study of primary cutaneous MCL.
  • To detail the clinical, histopathological, immunohistochemical, and molecular aspects.
  • To contribute to the understanding of this rare lymphoma subtype.

Main Methods:

  • Clinical case presentation.
  • Histopathological examination of skin biopsy.
  • Immunohistochemical analysis for cell markers.
  • Molecular characterization of the lymphoma cells.

Main Results:

  • Detailed description of the patient's presentation and disease course.
  • Characterization of the specific B-cell population involved.
  • Confirmation of cyclin D1 overexpression.
  • Identification of unique molecular findings.

Conclusions:

  • Primary cutaneous MCL requires thorough diagnostic evaluation.
  • Understanding its characteristics is crucial for appropriate management.
  • This case adds to the literature on rare cutaneous lymphomas.