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Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Skin Cancer01:30

Skin Cancer

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The Retinoblastoma Gene

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Published on: August 9, 2024

Pigmented viral-associated conjunctival carcinoma.

Norman C Charles1, Brian P Marr, Susan M Stenson

  • 1Department of Ophthalmology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA ; Department of Pathology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.

Case Reports in Ophthalmological Medicine
|June 14, 2013
PubMed
Summary

A rare case of conjunctival squamous cell carcinoma linked to human papillomavirus 16 was observed, even in sun-unexposed areas. Treatment involved cryosurgery, interferon, and surgical excision for ocular tumors.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Virology

Background:

  • Conjunctival squamous cell carcinoma (SCC) is a malignancy of the eye's surface.
  • While often associated with UV exposure, other risk factors are being investigated.
  • Human papillomavirus (HPV) has been implicated in various squamous cell carcinomas.

Purpose of the Study:

  • To report a unique case of conjunctival SCC.
  • To identify the potential causative agent in a sun-protected ocular tumor.
  • To describe the treatment modalities used.

Main Methods:

  • Clinical case presentation of a 54-year-old woman with ocular tumors.
  • In situ hybridization to detect viral DNA in tumor tissue.
  • Surgical and medical interventions for conjunctival lesions.

Main Results:

  • A pigmented papillary SCC was diagnosed in the conjunctiva of the right eye, an area lacking sun exposure.
  • In situ hybridization confirmed the presence of human papillomavirus 16 (HPV 16) within the tumor.
  • The left eye exhibited a nonpigmented conjunctival dysplasia, treated with excision.

Conclusions:

  • This case highlights HPV 16 as a potential oncogenic factor in conjunctival SCC, independent of UV radiation.
  • Ocular surface tumors may have varied etiologies requiring tailored treatment approaches.
  • Combined cryosurgery, interferon alfa 2b, and surgical excision can be effective for managing conjunctival malignancies and dysplasia.