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Solitary polypoid laryngeal xanthoma
Francisco Vera-Sempere1, Diego Collado-Martín, Beatriz Vera-Sirera
1Department of Pathology, La Fe University Hospital, School of Medicine and Dentistry, University of Valencia, Avenida Campanar 21, 46009 Valencia, Spain.
Case Reports in Otolaryngology
|June 14, 2013
Summary
A rare laryngeal xanthoma was found in a patient with long-standing human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. Antiretroviral therapy may play a role in the development of this unusual laryngeal lesion.
Area of Science:
- Otorhinolaryngology
- Pathology
- Infectious Diseases
Background:
- A 51-year-old male with diabetes, hyperlipidaemia, and a history of HIV/HCV infection presented with progressive dysphonia.
- The patient had a history of various antiretroviral treatments for his HIV infection.
Purpose of the Study:
- To report an unusual case of a laryngeal xanthoma.
- To investigate the potential link between antiretroviral treatment and laryngeal xanthoma development.
Main Methods:
- Fibre-optic laryngoscopy was performed to visualize the laryngeal lesion.
- Pathological analysis, including immunohistochemistry (CD68, perilipin, adipophilin), was conducted on the polyp.
Main Results:
- A solitary, yellowish-white pedunculated polyp was identified on the left vocal cord.
- Pathology confirmed a polypoid laryngeal xanthoma, immunoreactive for CD68, perilipin, and adipophilin.
Conclusions:
- The findings suggest a possible role of antiretroviral treatment in the pathogenesis of laryngeal xanthomas.
- This case highlights an unusual laryngeal manifestation in patients with HIV/HCV co-infection on antiretroviral therapy.
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