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Updated: May 10, 2026
06:54
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
Thwarting galectin-induced immunosuppression in breast cancer
Mariana Salatino1, Tomas Dalotto-Moreno, Gabriel A Rabinovich
1Laboratorio de Inmunopatología; Instituto de Biología y Medicina Experimental (IBYME-CONICET); Buenos Aires, Argentina.
Oncoimmunology
|June 14, 2013
Abstract:
Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4+CD25+ FOXP3+ regulatory T cells.
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