Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Equity Theory

Equity Theory

Equity theory explains how our sense of fairness influences the dynamics of close relationships. Rooted in social psychology, the theory posits that individuals evaluate fairness by comparing the ratio of their contributions to the rewards they receive. Relationship satisfaction is highest when these ratios are perceived as balanced between partners, promoting mutual reciprocity and a sense of justice.Equity vs. Equality in RelationshipsEquity is distinct from equality. Fairness does not...

Equilibrium and Balance

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...

Homeostatic Imbalance

Homeostatic Imbalance

Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...

Traits, Mood, and Subjective Wellbeing

Traits, Mood, and Subjective Wellbeing

Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
Neuroticism and Emotional...

Equilibrium Conditions for a Particle

Equilibrium Conditions for a Particle

When an object is in equilibrium, it is either at rest or moving with a constant velocity. There are two types of equilibrium: static and dynamic. Static equilibrium occurs when an object is at rest, while dynamic equilibrium occurs when an object is moving with a constant velocity. In both cases, there must be a balance of forces acting on the object.
To understand the concept of equilibrium, let us first consider the forces acting on an object. When different forces act on an object, they can...

Oscillations about an Equilibrium Position

Oscillations about an Equilibrium Position

Stability is an important concept in oscillation. If an equilibrium point is stable, a slight disturbance of an object that is initially at the stable equilibrium point will cause the object to oscillate around that point. For an unstable equilibrium point, if the object is disturbed slightly, it will not return to the equilibrium point. There are three conditions for equilibrium points—stable, unstable, and half-stable. A half-stable equilibrium point is also unstable, but is named so because...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Systemic viral vector vaccination induces brain resident memory T cells to drive anti-glioblastoma immunity.

bioRxiv : the preprint server for biology·2026

Same author

Inhibition of chemokine CXCL12 modulates the tumor microenvironment in glioblastoma and potentiates immune checkpoint inhibitor efficacy in a tissue-specific manner.

Neuro-oncology advances·2026

Same author

Assessing T-cell responses to Epstein-Barr virus in individuals at risk for nasopharyngeal carcinoma.

Infectious agents and cancer·2026

Same author

Increased immunogenicity of hypermutated SB28 syngeneic glioblastoma is partially mediated by alterations in tumor chemokine expression.

Neuro-oncology advances·2026

Same author

Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-neutrophil axis.

Neuro-oncology advances·2025

Same author

Enhancing DC cancer vaccine by allogeneic MHC class II expression and Treg depletion.

JCI insight·2025

Search research articles

Related Experiment Video

Updated: May 10, 2026

A Vibrotactile Feedback Device for Seated Balance Assessment and Training

A Vibrotactile Feedback Device for Seated Balance Assessment and Training

Published on: January 20, 2019

Balance is a key for happiness.

Liat Izhak¹, Jay A Berzofsky, Masaki Terabe

¹Vaccine Branch; Center for Cancer Research; National Cancer Institute, NIH; Bethesda, MD USA.

|June 14, 2013

Summary

Targeting cancer immunity requires understanding complex cell interactions. The balance between regulatory T cells (Tregs) and natural killer T (NKT) cells, influenced by their type I counterparts, determines if Treg removal effectively reduces immunosuppression.

Keywords:

NKT cells immune regulation immunosuppression regulatory T cells tumor immunology

More Related Videos

Assessment of Motor Balance and Coordination in Mice using the Balance Beam

Assessment of Motor Balance and Coordination in Mice using the Balance Beam

Published on: March 10, 2011

Related Experiment Videos

Last Updated: May 10, 2026

A Vibrotactile Feedback Device for Seated Balance Assessment and Training

A Vibrotactile Feedback Device for Seated Balance Assessment and Training

Published on: January 20, 2019

Assessment of Motor Balance and Coordination in Mice using the Balance Beam

Assessment of Motor Balance and Coordination in Mice using the Balance Beam

Published on: March 10, 2011

Area of Science:

Immunology
Cancer Biology
Immunotherapy

Background:

Cancer immunosuppression involves multiple regulatory mechanisms.
Regulatory T cells (Tregs) and type II natural killer T (NKT) cells are key players in tumor immunosuppression.
The interplay between different immune cell populations complicates single-target therapeutic strategies.

Purpose of the Study:

To investigate the complex interactions between regulatory T cells (Tregs), type II natural killer T (NKT) cells, and their type I counterparts in the context of cancer immunosuppression.
To determine if eliminating Tregs alone is sufficient to overcome cancer-induced immunosuppression, considering the influence of NKT cells.

Main Methods:

Analysis of immune cell populations within the tumor microenvironment.
Investigating the functional cross-talk between Tregs, type I NKT cells, and type II NKT cells.
Evaluating the impact of Treg depletion on overall immunosuppressive capacity.

Main Results:

The dominance of immunosuppression by Tregs or type II NKT cells is contingent upon their interactions with type I NKT cells.
Eliminating Tregs may not alleviate immunosuppression if the balance is maintained by other interacting cell types.
The intricate network of interactions among these three cell types dictates the overall immune response.

Conclusions:

Single-agent therapies targeting only Tregs are unlikely to be sufficient for effective cancer immunotherapy.
Understanding the balance and interactions between Tregs, type I NKT cells, and type II NKT cells is crucial for developing successful immunotherapies.
Future cancer immunotherapies should consider modulating the complex interplay of multiple immunomodulatory cell types.