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Methotrexate-induced pulmonary toxicity

Baruch D Jakubovic1, Andrea Donovan, Peter M Webster

  • 1Faculty of Medicine, University of Toronto, Toronto, Ontario.

Canadian Respiratory Journal
|June 14, 2013
PubMed

Insights

Methotrexate can cause lung inflammation (pneumonitis), a rare side effect. This case highlights key findings for diagnosing and managing this adverse reaction in psoriasis patients.

Area of Science:

  • Pulmonology
  • Dermatology
  • Pharmacology

Background:

  • Methotrexate is a common immunosuppressive drug.
  • It is frequently used for treating psoriasis.
  • Methotrexate has known adverse effects, including potential lung toxicity.

Observation:

  • A case report of a patient with psoriasis is presented.
  • The patient developed methotrexate-induced pneumonitis.
  • This highlights an infrequently encountered diagnosis.

Findings:

  • The report details hallmark clinical and investigational findings.
  • These findings support the diagnosis of methotrexate-induced pneumonitis.
  • The discussion covers pathogenesis, management, and prevention.

Implications:

  • Early recognition of methotrexate-induced pneumonitis is crucial.
  • Understanding the adverse drug reaction aids in patient management.
  • This case contributes to awareness of rare methotrexate side effects.

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