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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Topical nicotinamide for seborrheic dermatitis: an open randomized study.

Gabriella Fabbrocini¹, Mariateresa Cantelli, Giuseppe Monfrecola

¹Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II , Naples , Italy.

The Journal of Dermatological Treatment

|June 15, 2013

Summary

Topical nicotinamide (NCT) cream significantly improved seborrheic dermatitis symptoms. Patients using NCT showed a 75% reduction in facial seborrheic dermatitis scores compared to 35% with placebo.

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Area of Science:

Dermatology
Pharmacology

Background:

Seborrheic dermatitis (SD) presents treatment challenges with varying efficacy and safety profiles.
Current therapeutic options for SD have limitations.

Purpose of the Study:

To assess the effectiveness of topical nicotinamide (NCT) in managing seborrheic dermatitis.
Investigate NCT 4% cream as a potential treatment for facial SD.

Main Methods:

A randomized study involving 48 patients with mild to moderate facial SD.
Participants received either topical NCT 4% cream or a placebo vehicle daily.
Clinical assessments of erythema, scaling, and infiltration were recorded at baseline and after 2, 6, and 12 weeks.

Main Results:

Patients treated with topical NCT 4% experienced a 75% reduction in overall symptom scores from baseline.
The placebo group showed a 35% reduction in symptom scores (p < 0.05).
NCT demonstrated statistically significant improvement compared to the vehicle control.

Conclusions:

Topical nicotinamide 4% cream shows promise as an effective treatment for seborrheic dermatitis.
NCT offers a potential therapeutic option for patients with facial SD.
Further research may validate NCT's role in SD management.