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Polymorphism of C3 complement in association with myocardial infarction in a sample of central Tunisia

Nadia Leban1, Karim Jraba, Abdelkader Chalghoum

  • 1Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, Street Avicenne, 5019 Monastir, Tunisia. lebannadia@yahoo.fr.

Diagnostic Pathology
|June 15, 2013
PubMed

Insights

Genetic analysis revealed a significant association between the C3 complement polymorphism and myocardial infarction (MI). The C3*F allele strongly correlates with an increased risk of developing MI, highlighting its potential as a genetic marker for the disease.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Myocardial infarction (MI) is a leading cause of mortality globally.
  • Genetic factors play a crucial role in MI susceptibility.
  • Understanding genetic markers for MI risk is vital for prevention and treatment.

Purpose of the Study:

  • To investigate the correlation between the C3 complement polymorphism and myocardial infarction.
  • To identify specific C3 alleles associated with increased MI risk.

Main Methods:

  • A case-control study was conducted with 170 MI survivors and 95 healthy controls.
  • C3 allele identification was performed using amplification refractory mutation system PCR.
  • C3*S and C3*F alleles of the C3 polymorphism were analyzed.

Main Results:

  • The frequency of C3*S and C3*F alleles in MI patients was 0.59 and 0.41, respectively.
  • A significant increase in the C3*F allele was observed in MI patients (0.41) compared to controls (0.21).
  • The C3*F allele showed a strong positive correlation with MI risk (odds ratio: 2.616).

Conclusions:

  • A significant positive correlation exists between C3 polymorphism and myocardial infarction.
  • The C3*F allele is associated with a substantially increased risk of MI.
  • C3 polymorphism, particularly the C3*F allele, may serve as a valuable genetic marker for MI.
Abstract

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