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Asynchronous onset of clinical disease in BSE-infected macaques
Judith Montag1, Walter Schulz-Schaeffer, Annette Schrod
1German Primate Center, Göttingen, Germany.
Emerging Infectious Diseases
|June 15, 2013
Abstract:
To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected.
