Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain white matter microstructural integrity differences between pre-post buprenorphine-naloxone treated individuals with opioid use disorder: Evidence from a DTI study.

Psychiatry research. Neuroimaging·2026
Same author

Invasive mould infections of the central nervous system in the Indian population: a cohort study (2004-2025).

The Lancet regional health. Southeast Asia·2026
Same author

Role of Advanced Multimodality Synthetic MRI and Dynamic Contrast-Enhanced MRI Derived Parameters in the Differentiating Neurocysticercosis and Tuberculomas.

Clinical neuroradiology·2026
Same author

Patterns and Factors Associated With Cerebral Infarction on MRI in Tuberculous Meningitis: Secondary Analysis of the ACT-TBM Trial.

Stroke·2026
Same author

Buprenorphine and Surface-based Brain Morphometry: Impacts on Cortical Thickness, Depth, and Gyrification in Patients with Opioid Use Disorder.

Indian journal of psychological medicine·2025
Same author

Diagnosing tuberculous meningitis from cell-free DNA by multi-targeted real-time PCR: An experience from 170 cases.

Tuberculosis (Edinburgh, Scotland)·2025
Same journal

Patient- and ward-level determinants of psychosomatic-psychiatric consultations for mentally distressed inpatients from medical hospitals: Findings from the SomPsyNet stepped-wedge-trial.

General hospital psychiatry·2026
Same journal

Self-stigma as a central barrier to psychological help-seeking among patients receiving ambulatory Orthopedic care: Paradoxical associations of anxiety and depressive symptoms.

General hospital psychiatry·2026
Same journal

Therapeutic approaches for functional Globus Pharyngeus: A systematic review of studies from 2000 to 2025.

General hospital psychiatry·2026
Same journal

Quetiapine Versus Haloperidol for the Treatment of Delirium in Hospitalized Adults: A Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.

General hospital psychiatry·2026
Same journal

DASA score performance for predicting safety interventions among patients with and without emergency behavioral health consultation need: A cross-sectional study.

General hospital psychiatry·2026
Same journal

Postoperative delirium severity reflects baseline vulnerability more than measured postoperative exposures: A longitudinal analysis.

General hospital psychiatry·2026
See all related articles

Related Experiment Videos

Bupropion-induced hyponatremia.

Natasha Kate, Sandeep Grover, Santhosh Kumar

    General Hospital Psychiatry
    |June 15, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Bupropion, an antidepressant, can cause hyponatremia (low sodium levels). This case report details a 75-year-old man who experienced hyponatremia while taking bupropion, which resolved after discontinuing the medication.

    Keywords:
    BupropionHyponatremia

    Related Experiment Videos

    Area of Science:

    • Neuroscience
    • Clinical Pharmacology
    • Endocrinology

    Background:

    • Hyponatremia is a known potential side effect of various antidepressant medications.
    • Previous reports linking bupropion to hyponatremia are limited, with only two case reports documented.
    • Understanding the full spectrum of antidepressant-induced adverse effects is crucial for patient safety.

    Observation:

    • A 75-year-old male patient presented with symptoms indicative of hyponatremia.
    • The patient was concurrently using bupropion for antidepressant therapy.

    Findings:

    • The patient developed hyponatremia during bupropion treatment.
    • Discontinuation of bupropion led to the resolution of hyponatremia, establishing a probable causal link.

    Implications:

    • This case adds to the limited evidence associating bupropion with hyponatremia.
    • Clinicians should consider bupropion as a potential cause of hyponatremia in patients, particularly the elderly.
    • Monitoring electrolyte levels may be warranted in patients initiating or adjusting bupropion therapy.