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Updated: May 10, 2026

Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays
Published on: June 18, 2016
On guard: coronin proteins in innate and adaptive immunity
Jean Pieters1, Philipp Müller, Rajesh Jayachandran
1Biozentrum, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. jean.pieters@unibas.ch
Abstract:
Recent work has implicated members of the evolutionarily conserved family of coronin proteins - in particular coronin 1 - in immune homeostasis. Coronins are involved in processes as diverse as pathogen survival in phagocytes and homeostatic T cell signalling. Notably, in both mice and humans, coronin mutations are associated with immune deficiencies and resistance to autoimmunity. In this article, we review what is currently known about these conserved molecules and discuss a potential common mechanism that underlies their diverse activities, which seem to involve cytoskeletal interactions as well as calcium-calcineurin signalling.
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