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Determination of thiabendazole, 5-hydroxythiabendazole, fenbendazole, and oxfendazole in milk
S S Tai1, N Cargile, C J Barnes
1National Institute of Standards and Technology, Organic Analytical Division, Gaithersburg, MD 20899.
Abstract:
The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10 ppb level were 80% or greater with an intralaboratory coefficient of variation of 11% or less. Recovery of 5-hydroxythiabendazole (5-OH-TBZ) at the 30 ppb level averaged 56% with an intralaboratory coefficient of variation of 5%. Limited data on the depletion of FBZ, OFZ, TBZ, and 5-OH-TBZ in milk were also generated.