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Functional genomics to identify therapeutic prophylactic targets.

Christian G Frank¹, José A Bengoechea

¹Program Infection and Immunity, Fundación Caubet-CIMERA Illes Balears, Recinto Hospital Joan March, Carretera Soller Km 12, 07110 Bunyola, Spain. Area Molecular basis of microbial pathogenesis, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES) Bunyola, Spain. Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

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Summary

Developing new antimicrobial therapies is crucial due to rising drug resistance. This review explores innovative host-directed drug strategies and targeting microbial virulence factors to combat infectious diseases effectively.

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Published on: August 25, 2021

Area of Science:

Microbiology
Drug Discovery
Genomics

Background:

Infectious diseases are a major global cause of death.
Antimicrobial resistance necessitates novel therapeutic strategies.
Current treatments face challenges from drug-resistant pathogens.

Purpose of the Study:

To review a new drug discovery paradigm.
To focus on host factors and pathogen determinants for therapeutic targeting.
To highlight innovative strategies for identifying essential host factors.

Main Methods:

Integration of bioinformatics, transcriptomics, and chemical genetics.
Utilizing RNA interference for functional genomic studies in human cells.
Identifying host factors crucial for pathogen entry, survival, and replication.

Main Results:

Identification of host factors essential for pathogen lifecycle stages.
Advancement of functional genomic studies through RNA interference.
Development of strategies combining host-directed therapies with antimicrobial approaches.

Conclusions:

Host-directed drug therapy offers a promising avenue against infectious diseases.
Targeting microbial virulence factors complements traditional antimicrobial strategies.
Combined approaches are expected to enhance pathogen elimination and combat resistance.