Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetic protocol for predicting plasma haloperidol concentrations.

D D Miller1, P J Perry, M W Kelly

  • 1Department of Psychiatry, College of Medicine, University of Iowa, Iowa City.

Journal of Clinical Psychopharmacology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Antimitotic Agent SP-1-39 Inhibits Head and Neck Squamous Cell Carcinoma.

Journal of dental research·2024
Same author

Synergistic Effects of Temperature and Salinity on the Gene Expression and Physiology of Crassostrea virginica.

Integrative and comparative biology·2019
Same author

Mycobacterium immunogenum folliculitis on the lower extremities of a healthy young adult.

Clinical and experimental dermatology·2018
Same author

Journal of Nuclear Cardiology Nuclear Cardiology News Update.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2016
Same author

Agriculture. Research principles for developing country food value chains.

Science (New York, N.Y.)·2011
Same author

Action of nifedipine in ischemic heart disease.

Canadian family physician Medecin de famille canadien·2011
Same journal

Are the 8 Finnish Deaths Explained by Agranulocytosis More Important than the Thousands of Suicide Deaths Associated with the Lack of Use of Clozapine? Reflections on Clozaphobia.

Journal of clinical psychopharmacology·2026
Same journal

Aripiprazole Withdrawal-Associated Restless Legs Syndrome During Clozapine Treatment in an Adolescent With Schizoaffective Disorder: A Case Report.

Journal of clinical psychopharmacology·2026
Same journal

Salute to Our Reviewers.

Journal of clinical psychopharmacology·2026
Same journal

Article Selected to Receive the Mitchell B. Balter Award for Publications in 2025.

Journal of clinical psychopharmacology·2026
Same journal

Pregnancy Outcomes After First-Trimester Exposure to Vortioxetine: Prospective Outcomes From the MGH National Pregnancy Registry for Psychiatric Medications.

Journal of clinical psychopharmacology·2026
Same journal

Salute to Our Reviewers.

Journal of clinical psychopharmacology·2026
See all related articles

Accurate prediction of steady-state haloperidol levels is possible with a kinetic method using two blood samples. Dosing predictions become less precise above 0.47 mg/kg/day, suggesting potential dose-dependent pharmacokinetics.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Drug Monitoring

Background:

  • Accurate prediction of drug concentrations is crucial for therapeutic drug monitoring.
  • Haloperidol is an antipsychotic medication requiring careful dosage adjustments.

Purpose of the Study:

  • To evaluate the accuracy of two methods for predicting steady-state plasma haloperidol concentrations.
  • To identify potential limitations in predictive methods at higher dosages.

Main Methods:

  • A kinetic method involving two blood samples after a 20 mg test dose.
  • A dose method based on mg/kg/day dosage calculations.

Main Results:

  • The kinetic method accurately predicted steady-state haloperidol concentrations.

Related Experiment Videos

  • Both methods showed reduced precision when daily doses exceeded 0.47 mg/kg/day.
  • Fifty percent of concentrations were underpredicted above this threshold, indicating potential dose-dependent pharmacokinetics.

    • Conclusions:

    • The kinetic method provides accurate prediction of steady-state haloperidol plasma concentrations.
    • Higher haloperidol doses may exhibit dose-dependent pharmacokinetics, impacting prediction accuracy.