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Updated: May 10, 2026

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Synthesis and transformations of novel L-phenylalanine derived pyrazolidin-3-ones
Uroš Grošelj1, Amalija Golobič, Jurij Svete
1University of Ljubljana, Faculty of Chemistry and Chemical Technology, Aškerčeva cesta 5, P.O. Box 537, SI-1000 Ljubljana, Slovenia. uros.groselj@fkkt.uni-lj.si
Abstract:
A simple and straightforward four-step synthesis of novel diastereomeric L-phenylalanine-derived pyrazolidin-3-ones is described. The absolute configuration of the novel C(5) stereogenic centre has been unambiguously determined by single crystal X-ray analysis and via chemical interconversions. A series of novel thiourea derived pyrazolidinones have been prepared and tested as potential organocatalysts. N(1) un-substituted pyrazolidinones can be used for the construction of a novel type of bicyclic heterocycles and other selective derivatizations.
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