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Elevated galectin-3 precedes the development of CKD.

Conall M O'Seaghdha¹, Shih-Jen Hwang, Jennifer E Ho

¹National Heart, Lung, and Blood Institute's Intramural Research Program, Framingham Heart Study, Massachusetts, USA.

Journal of the American Society of Nephrology : JASN

|June 15, 2013

Summary

Elevated galectin-3 levels are linked to a higher risk of rapid kidney function decline and chronic kidney disease (CKD) development in the general population. Further research is needed to confirm these findings in at-risk groups.

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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Area of Science:

Nephrology
Biomarkers
Epidemiology

Background:

Galectin-3 is a profibrotic mediator implicated in kidney fibrosis.
Previous studies show an inverse correlation between galectin-3 and glomerular filtration rate (GFR) in humans.
The predictive value of galectin-3 for incident kidney disease remains unclear.

Purpose of the Study:

To investigate the association between plasma galectin-3 levels and the incidence of renal outcomes.
To assess galectin-3 as a predictor of rapid GFR decline, chronic kidney disease (CKD), and albuminuria.

Main Methods:

Longitudinal study of 2450 Framingham Offspring participants with a mean follow-up of 10.1 years.
Assessment of renal outcomes including rapid GFR decline, incident CKD, and incident albuminuria.
Multivariable logistic regression models were used to analyze associations between galectin-3 and renal outcomes.

Main Results:

Higher plasma galectin-3 levels were significantly associated with a rapid decline in estimated GFR (eGFR) and incident CKD.
No significant association was found between galectin-3 and incident albuminuria.
Galectin-3 improved the C-statistic for risk prediction but did not meet predefined thresholds for clinical significance.

Conclusions:

Elevated plasma galectin-3 is associated with an increased risk of rapid GFR decline and incident CKD in the community.
These findings suggest galectin-3 may serve as a potential biomarker for kidney disease progression.
Further investigation in higher-risk populations is warranted to validate these results.