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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Alternative splicing for diseases, cancers, drugs, and databases

Jen-Yang Tang1, Jin-Ching Lee, Ming-Feng Hou

  • 1Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Thescientificworldjournal
|June 15, 2013
PubMed

Insights

Alternative splicing dysregulation is linked to diseases like cancer. Correcting alternative splicing offers a therapeutic strategy, with several drugs and natural products showing potential in modulating these processes for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Alternative splicing is a key process for generating protein diversity from a limited genome.
  • Dysregulation of alternative splicing is implicated in various diseases, notably cancer.
  • Targeting spliceosomes represents a promising avenue for novel cancer therapeutics.

Purpose of the Study:

  • To review diseases associated with alternative splicing dysregulation, focusing on cancer.
  • To analyze the effects of clinical drugs, natural products, and derivatives on alternative splicing.
  • To discuss other agents that modulate alternative splicing in cancer therapy.

Main Methods:

  • Literature review of alternative splicing-related diseases and their target genes.
  • Analysis of existing data on drugs and natural products affecting spliceosomes and alternative splicing.
  • Summary of relevant bioinformatics resources for studying alternative splicing.

Main Results:

  • Identified specific cancers and their associated target genes linked to alternative splicing.
  • Evaluated the impact of various compounds, including clinical drugs and natural products, on alternative splicing.
  • Highlighted agents with demonstrated or potential roles in modulating alternative splicing during cancer treatment.

Conclusions:

  • Alternative splicing dysregulation is a significant factor in cancer development and progression.
  • Modulating alternative splicing presents a viable therapeutic strategy for cancer.
  • Further research into splicing-modulating agents and bioinformatics tools is crucial for advancing cancer therapy.

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