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Updated: May 10, 2026
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
Published on: April 26, 2017
Alternative splicing for diseases, cancers, drugs, and databases
Jen-Yang Tang1, Jin-Ching Lee, Ming-Feng Hou
1Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Thescientificworldjournal
|June 15, 2013
Summary
Alternative splicing dysregulation is linked to diseases like cancer. Correcting alternative splicing offers a therapeutic strategy, with several drugs and natural products showing potential in modulating these processes for cancer treatment.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Alternative splicing is a key process for generating protein diversity from a limited genome.
- Dysregulation of alternative splicing is implicated in various diseases, notably cancer.
- Targeting spliceosomes represents a promising avenue for novel cancer therapeutics.
Purpose of the Study:
- To review diseases associated with alternative splicing dysregulation, focusing on cancer.
- To analyze the effects of clinical drugs, natural products, and derivatives on alternative splicing.
- To discuss other agents that modulate alternative splicing in cancer therapy.
Main Methods:
- Literature review of alternative splicing-related diseases and their target genes.
- Analysis of existing data on drugs and natural products affecting spliceosomes and alternative splicing.
- Summary of relevant bioinformatics resources for studying alternative splicing.
Main Results:
- Identified specific cancers and their associated target genes linked to alternative splicing.
- Evaluated the impact of various compounds, including clinical drugs and natural products, on alternative splicing.
- Highlighted agents with demonstrated or potential roles in modulating alternative splicing during cancer treatment.
Conclusions:
- Alternative splicing dysregulation is a significant factor in cancer development and progression.
- Modulating alternative splicing presents a viable therapeutic strategy for cancer.
- Further research into splicing-modulating agents and bioinformatics tools is crucial for advancing cancer therapy.
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There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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