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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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Related Experiment Video

Updated: May 10, 2026

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis
08:16

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

Published on: February 26, 2019

Angiogenesis and endometriosis.

Ana Luiza L Rocha1, Fernando M Reis, Robert N Taylor

  • 1Department of Obstetrics and Gynecology, Division of Human Reproduction, Federal University of Minas Gerais, 310130-100 Belo Horizonte, MG, Brazil.

Obstetrics and Gynecology International
|June 15, 2013
PubMed
Summary
This summary is machine-generated.

Angiogenesis, the formation of new blood vessels, is crucial for endometriosis development and survival. Antiangiogenic agents show promise in treating endometriosis by reducing blood supply to lesions.

More Related Videos

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Related Experiment Videos

Last Updated: May 10, 2026

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis
08:16

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

Published on: February 26, 2019

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Area of Science:

  • Reproductive biology
  • Vascular biology
  • Gynecology

Background:

  • Endometriosis is a complex, multifactorial disease.
  • Implant survival depends on invasive capacity and angiogenic potential.
  • Peritoneal fluid in endometriosis patients contains factors promoting new blood vessel growth.

Purpose of the Study:

  • To review the role of angiogenesis in endometriosis pathogenesis.
  • To explore the potential of antiangiogenic therapies for endometriosis.

Main Methods:

  • Comprehensive literature review.
  • Analysis of experimental studies on antiangiogenic agents in endometriosis models.

Main Results:

  • Angiogenesis supports endometriotic implant survival and growth.
  • Antiangiogenic agents have demonstrated lesion regression in experimental studies.
  • Reduced blood supply is a key mechanism for antiangiogenic effects.

Conclusions:

  • Angiogenesis is a critical factor in endometriosis.
  • Antiangiogenic therapies represent a potential treatment strategy.
  • Further research is needed to establish safety, especially for women desiring pregnancy.