Effect of Phellius linteus water extract on benign prostatic hyperplasia

Area of Science:

• Urology
• Pharmacology
• Natural Product Research

Background:

• Benign prostatic hyperplasia (BPH) is a common condition in aging men, characterized by prostate enlargement.
• Dihydrotestosterone (DHT) plays a key role in promoting prostate growth in BPH.
• Current treatments often involve managing DHT levels, highlighting the need for effective therapeutic agents.

Purpose of the Study:

• To investigate the potential of Phellinus linteus water extract as a treatment for BPH.
• To evaluate the effects of Phellinus linteus on prostate size, weight, and hormone levels in a rat model of BPH.

Main Methods:

• Benign prostatic hyperplasia (BPH) was induced in Sprague-Dawley rats using testosterone treatments over 12 weeks.
• Rats were divided into four groups: control, testosterone + D.W. extract, testosterone + Phellinus linteus extract, and testosterone + finasteride.
• Prostate weight, volume, testosterone, and DHT levels were measured and compared across groups.

Main Results:

• Phellinus linteus extract significantly reduced prostate weight, volume, and weight ratio compared to the untreated BPH group.
• Testosterone and DHT levels were significantly decreased in the Phellinus linteus group compared to the untreated BPH group.
• Histological analysis showed reduced stromal proliferation and trophic changes in prostates treated with Phellinus linteus.

Conclusions:

• Phellinus linteus water extract demonstrates efficacy in reducing prostate enlargement and DHT levels in a BPH rat model.
• The findings suggest Phellinus linteus may serve as a potential natural remedy for managing benign prostatic hyperplasia.
• Further research is warranted to explore the mechanisms and clinical applications of Phellinus linteus for BPH treatment.