Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Introduction to Language of Pathophysiology l

Introduction to Language of Pathophysiology l

Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Brain tight junction protein expression in sepsis in an autopsy series.

Critical care (London, England)·2020

Same author

Immune cell score in pancreatic cancer-comparison of hotspot and whole-section techniques.

Virchows Archiv : an international journal of pathology·2019

Same author

FOXP3<sup>+</sup> T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome.

Pediatric nephrology (Berlin, Germany)·2017

Same author

Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma.

Histopathology·2017

Same author

Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas.

Histology and histopathology·2016

Same author

Toll-like receptor 9 expression in the natural history of Barrett mucosa.

Virchows Archiv : an international journal of pathology·2015

Search research articles

Related Experiment Video

Updated: May 10, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

[Pathology is much more than tumor diagnostics].

Tuomo Karttunen¹, Paavo Pääkkö

¹Oulun yliopiston diagnostiikan laitoksen patologian yksikkö ja OYS.

Duodecim; Laaketieteellinen Aikakauskirja

|June 18, 2013

Summary

Pathologists classify inflammatory and degenerative diseases using histopathology, aiding diagnosis and prognosis. New methods reveal novel disease groups like IgG4-associated inflammatory diseases.

Area of Science:

Pathology
Histopathology
Immunopathology

Context:

The majority of a pathologist's workload involves non-neoplastic samples.
Accurate classification of inflammatory and degenerative diseases is crucial for patient treatment and prognosis.
Histopathologic analysis remains a cornerstone in assessing disease severity and guiding clinical decisions.

Purpose:

To highlight the significance of histopathologic analysis in classifying non-neoplastic diseases.
To emphasize the role of histopathology in determining disease severity and prognosis.
To showcase advancements in diagnostic methods leading to the identification of new disease entities.

Summary:

Histopathology is essential for classifying inflammatory and degenerative conditions, guiding treatment and predicting outcomes.

More Related Videos

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Published on: November 17, 2023

Related Experiment Videos

Last Updated: May 10, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

Published on: November 17, 2023

Negative histopathologic findings are valuable for directing further diagnostic investigations.

Emerging analytical techniques and biomarkers have facilitated the discovery of novel disease classifications, such as IgG4-associated inflammatory diseases.

Impact:

Improved diagnostic accuracy for a wide range of non-neoplastic conditions.
Enhanced ability to predict patient prognosis and tailor therapeutic strategies.
Facilitation of the identification and characterization of previously unrecognized disease groups, advancing medical knowledge.