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Retinoic acid syndrome--cardiac complication.

A K Dhar¹, P K Barman

¹Army Hospital (R&R), Delhi Cantt 110010.

The Journal of the Association of Physicians of India

|June 18, 2013

Summary

Retinoic acid syndrome, a complication of all-trans retinoic acid (ATRA) therapy in acute promyelocytic leukemia (APML), can cause fever and respiratory distress. This report details rare electrophysiological changes observed in a patient with APML during ATRA treatment.

Area of Science:

Hematology
Oncology
Pharmacology

Background:

Acute promyelocytic leukemia (APML) is treated with all-trans retinoic acid (ATRA).
Retinoic acid syndrome (RAS) is a known complication of ATRA therapy.
RAS typically presents with fever and respiratory distress.

Observation:

A 16-year-old patient with APML undergoing ATRA treatment developed unusual symptoms.
Electrophysiological changes were observed in this patient.

Findings:

The patient exhibited electrophysiological abnormalities during ATRA therapy.
These findings represent a rare and previously unreported manifestation of RAS.

Implications:

Highlights the potential for diverse and rare complications associated with ATRA therapy in APML.

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Suggests the need for comprehensive monitoring, including electrophysiological assessments, in patients with APML receiving ATRA.

Contributes to a deeper understanding of the spectrum of Retinoic Acid Syndrome.