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Retinoic acid syndrome--cardiac complication
1Army Hospital (R&R), Delhi Cantt 110010.
The Journal of the Association of Physicians of India
|June 18, 2013
Summary
Retinoic acid syndrome, a complication of all-trans retinoic acid (ATRA) therapy in acute promyelocytic leukemia (APML), can cause fever and respiratory distress. This report details rare electrophysiological changes observed in a patient with APML during ATRA treatment.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Acute promyelocytic leukemia (APML) is treated with all-trans retinoic acid (ATRA).
- Retinoic acid syndrome (RAS) is a known complication of ATRA therapy.
- RAS typically presents with fever and respiratory distress.
Observation:
- A 16-year-old patient with APML undergoing ATRA treatment developed unusual symptoms.
- Electrophysiological changes were observed in this patient.
Findings:
- The patient exhibited electrophysiological abnormalities during ATRA therapy.
- These findings represent a rare and previously unreported manifestation of RAS.
Implications:
- Highlights the potential for diverse and rare complications associated with ATRA therapy in APML.
- Suggests the need for comprehensive monitoring, including electrophysiological assessments, in patients with APML receiving ATRA.
- Contributes to a deeper understanding of the spectrum of Retinoic Acid Syndrome.
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