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Related Experiment Video

Updated: May 10, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Gluten induced diseases].

P Frič¹, M Zavoral, T Dvořáková

¹Interni Klinika1. Lekarske fakulty UK a UVN - Vojenske Fakultni nemocnice Praha. premysl.fric@uvn.cz

Vnitrni Lekarstvi

|June 18, 2013

Summary

Gluten-induced diseases like celiac disease and wheat allergy stem from cereal introduction. Diagnosing non-celiac gluten sensitivity requires excluding other conditions and a gluten-free diet.

Area of Science:

Immunology
Gastroenterology
Nutrition Science

Context:

Cereal introduction 10,000 years ago linked to gluten-induced diseases.
Gluten complex implicated in wheat allergy, celiac disease, and gluten sensitivity.
Distinct immune mechanisms (adaptive vs. innate) differentiate these conditions.

Purpose:

To differentiate gluten-induced diseases based on immune mechanisms and clinical presentation.
To highlight diagnostic challenges and criteria for non-celiac gluten sensitivity.
To explore genetic factors and lack of biomarkers for gluten sensitivity.

Summary:

Wheat allergy and celiac disease involve adaptive immunity, while gluten sensitivity involves innate immunity.
Symptoms can be intestinal or extraintestinal; diagnostic differences include gut barrier permeability and histology.

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Gluten sensitivity diagnosis relies on exclusion and response to a gluten-free diet under controlled conditions.

Impact:

Clarifies the pathogenesis and diagnostic pathways for gluten-related disorders.
Underscores the need for precise diagnostic tools for gluten sensitivity.
Informs clinical practice regarding gluten intolerance management and research directions.