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Nox as a target for diabetic complications

Yves Gorin1, Karen Block

  • 1Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA. gorin@uthscsa.edu

Clinical Science (London, England : 1979)
|June 18, 2013
PubMed

Insights

NADPH oxidases (Nox) are key in diabetic complications like kidney, heart, and eye issues. Inhibiting Nox enzymes offers a promising therapeutic strategy to prevent or slow diabetes-related organ damage.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Oxidative stress is implicated in diabetic complications affecting organs like the kidney, heart, and vasculature.
  • NADPH oxidases (Nox) are significant sources of reactive oxygen species (ROS) and central to redox signaling in diabetic conditions.

Purpose of the Study:

  • To review the role of Nox enzymes in hyperglycemia-induced cell injury and diabetic complications.
  • To explore the involvement of factors like the renin-angiotensin system, TGF-β, and AGEs in Nox-mediated damage.
  • To assess the therapeutic potential of Nox inhibitors for diabetic complications.

Main Methods:

  • Literature review of current knowledge on Nox family enzymes in diabetes.
  • Analysis of studies investigating hyperglycemia, renin-angiotensin system, TGF-β, and AGEs in relation to Nox activity.
  • Evaluation of data on small-molecule Nox inhibitors and their efficacy in preclinical models.

Main Results:

  • Nox enzymes are critical mediators of cell injury in diabetes.
  • Hyperglycemia, renin-angiotensin system, TGF-β, and AGEs contribute to Nox-driven damage.
  • Small-molecule Nox inhibitors show promise in experimental models for preventing diabetic complications.

Conclusions:

  • Nox homologues play a crucial role in the pathogenesis of diabetic complications.
  • NADPH oxidases represent a significant therapeutic target for managing diabetes-related organ damage.
  • Development of selective Nox inhibitors is a viable strategy to mitigate diabetic complications.

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