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Novel drug discovery opportunities for colorectal cancer

Joshua C Curtin1

  • 1Oncology Drug Discovery, Research and Development, Bristol-Myers Squibb, Route 206 and Provinceline Road, Princeton, NJ, USA. Joshua.Curtin@bms.com

Expert Opinion on Drug Discovery
|June 18, 2013
PubMed
Abstract

Insights

Colorectal cancer (CRC) remains a major global health threat. Targeting developmental pathways like Notch and Wnt offers promising new therapeutic strategies for advanced CRC, addressing the need for improved patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide.
  • CRC pathogenesis involves genetic mutations, dysregulated signaling pathways (Notch, Wnt), and cancer stem cells.
  • Current therapies, including EGFR inhibitors, show promise but do not fully resolve advanced disease prognosis.

Purpose of the Study:

  • To review colorectal cancer statistics, anatomy, pathobiology, genetics, and therapies.
  • To discuss the role of developmental signaling pathways in CRC self-renewal biology.
  • To explore these pathways as potential targets for novel therapeutic interventions.

Main Methods:

  • Literature review of CRC statistics and pathobiology.
  • Analysis of CRC genetics and current/emerging treatment strategies.
  • Examination of developmental signaling pathways (Notch, Wnt) in CRC.

Main Results:

  • Advanced CRC prognosis remains poor despite targeted therapeutics.
  • Developmental pathways like Notch and Wnt are implicated in CRC self-renewal.
  • Preclinical evidence supports targeting these pathways for CRC treatment.

Conclusions:

  • Novel therapeutic interventions are crucial for improving advanced CRC outcomes.
  • Targeting Notch and Wnt pathways presents a promising avenue for CRC therapy.
  • Ongoing preclinical research shows encouraging potential for these novel strategies.

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