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Related Concept Videos

Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Related Experiment Video

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Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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Published on: July 27, 2022

Curcumin: a boon to colonic diseases.

Rashmi Sareen1, Nitin Jain, Vinay Pandit

  • 1School of Pharmaceutical Sciences, Shoolini University, Bajhol, Solan H.P., India. sareenrashmi@gmail.com

Current Drug Targets
|June 18, 2013
PubMed
Summary

Curcumin, a compound in turmeric, shows promise for bowel diseases due to its anti-inflammatory and anticancer effects. Novel delivery systems are needed to overcome its poor bioavailability for effective treatment.

Area of Science:

  • Pharmacology
  • Natural Products
  • Gastroenterology

Background:

  • Curcumin, derived from turmeric, possesses diverse pharmacological properties including anti-inflammatory, anticancer, and antioxidant activities.
  • Clinical studies suggest curcumin's potential in managing colonic diseases like ulcerative colitis, Crohn's disease, and colon cancer.
  • A significant challenge for curcumin's therapeutic application is its low solubility and poor bioavailability, limiting optimal absorption and cellular uptake.

Purpose of the Study:

  • To review the pharmacological activities and clinical evidence of curcumin in bowel disease chemoprevention.
  • To explore recent advancements in curcumin delivery systems aimed at enhancing cellular uptake and bioavailability.
  • To provide an overview of curcumin's background, pharmacology, and pharmacokinetics relevant to gastrointestinal applications.

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Main Methods:

  • Literature review of preclinical and clinical studies on curcumin and bowel diseases.
  • Analysis of research on novel formulation strategies and delivery systems for curcumin.
  • Synthesis of information on curcumin's mechanisms of action and pharmacokinetic profiles.

Main Results:

  • Curcumin demonstrates broad-spectrum pharmacological activities relevant to colonic health.
  • Evidence supports curcumin's potential role in the chemoprevention and treatment of inflammatory bowel diseases and colon cancer.
  • Various novel delivery systems are being developed to improve curcumin's solubility, bioavailability, and cellular penetration.

Conclusions:

  • Curcumin holds significant therapeutic potential for various colonic diseases.
  • Overcoming curcumin's bioavailability limitations through advanced delivery systems is crucial for clinical success.
  • Further research into optimized curcumin formulations is warranted for effective bowel disease management.