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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Spongy Bone

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Gross Anatomy of Bone

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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Staphylococcus aureus osteomyelitis: bad to the bone.

Michael E Olson1, Alexander R Horswill

  • 1Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Cell Host & Microbe
|June 18, 2013
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus causes bone infections like osteomyelitis. Researchers used microCT imaging to find that the enzyme aureolysin is key in how this infection affects bone remodeling.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Skeletal Biology

Background:

  • Osteomyelitis is a severe bone infection frequently caused by Staphylococcus aureus.
  • Understanding the mechanisms of bone destruction and remodeling during infection is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the role of Staphylococcus aureus virulence factors in modulating bone remodeling during osteomyelitis.
  • To develop and apply advanced imaging techniques for visualizing bone changes in vivo.

Main Methods:

  • Development of a high-resolution microcomputed tomography (microCT) method.
  • In vivo imaging of bone remodeling dynamics during Staphylococcus aureus infection in a model system.

Main Results:

  • The study visualized dynamic bone remodeling processes during Staphylococcus aureus infection using microCT.
  • The metalloprotease aureolysin was identified as a critical factor influencing osteomyelitis pathogenesis.
  • Aureolysin's role in modulating the host's bone response to infection was elucidated.

Conclusions:

  • High-resolution microCT is a valuable tool for studying bone infections.
  • The bacterial enzyme aureolysin significantly impacts the progression of osteomyelitis by affecting bone remodeling.
  • Targeting aureolysin may represent a novel therapeutic strategy for treating Staphylococcus aureus osteomyelitis.