Related Experiment Video
Updated: May 10, 2026
16:46
A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
Published on: June 3, 2014
Relationship between longitudinal strain and symptomatic status in aortic stenosis
David Attias1, Laurent Macron, Julien Dreyfus
1Department of Cardiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris, France.
Summary
Basal longitudinal strain (BLS), but not global longitudinal strain (GLS), independently predicts symptomatic status in aortic stenosis (AS) patients. However, variability in measurements warrants caution when using strain alone for clinical decisions in severe AS.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Imaging
Background:
- Aortic stenosis (AS) is a common valvular heart disease.
- Global longitudinal strain (GLS) and basal longitudinal strain (BLS) are emerging markers for left ventricular (LV) dysfunction.
- Their prognostic value in AS patients is under investigation.
Purpose of the Study:
- To assess the relationship between longitudinal strain parameters (GLS and BLS) and symptomatic status in patients with AS.
- To determine if GLS or BLS can predict symptoms in AS patients.
Main Methods:
- 171 patients with isolated AS were prospectively enrolled.
- Patients were categorized into four groups based on AS severity, symptoms, and LV ejection fraction (LVEF).
- GLS and BLS were measured using 2D speckle-tracking imaging.
Main Results:
- Both GLS and BLS showed significant differences across the four patient groups.
- GLS was not an independent predictor of symptomatic status after multivariate analysis.
- BLS was independently associated with symptomatic status, but with considerable overlap between groups.
Conclusions:
- Basal longitudinal strain (BLS) is independently associated with symptomatic status in AS patients.
- Global longitudinal strain (GLS) is not an independent predictor of symptoms in this cohort.
- The overlap and variability in strain measurements suggest caution in using longitudinal strain as a sole criterion for clinical decision-making in severe AS.
Keywords:
ALSASAUCAVAAortic Stenosis in Elderly: Determinant of ProgressionAortic stenosisAortic valve areaApical longitudinal strainArea under the receiver operating characteristic curveBLSBasal longitudinal strainCADCOFRASACoronary artery diseaseEchocardiographyGENERACGLSGenetic of Aortic Valve Stenosis: Clinical and Therapeutic ImplicationsGlobal longitudinal strainLVLVEFLeft ventricularLeft ventricular ejection fractionLongitudinal strainMPGMean pressure gradientSpeckle-tracking
Related Concept Videos
01:20Normal Strain under Axial Loading
Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
01:10Stress-Strain Diagram
A stress-strain diagram is a crucial tool that graphically displays a material's mechanical characteristics. This diagram is derived from a tensile test performed on a carefully prepared cylindrical specimen. The specimen has two gauge marks inscribed on its central part, and the distance between these marks is known as the gauge length. The cylindrical specimen is placed in a testing machine, which applies an increasing centric load. As this load grows, so does the gauge length. This change in...
01:28True Stress and True Strain
Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
01:15Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...