Inhibitory effect of the paraoxonase gene on the formation of rabbit coronary atherosclerosis
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Updated: May 10, 2026
The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
Published on: October 3, 2017
Jing Bai1, Hui Zhou, Xin-Hong Yang
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Jingbaicn@yahoo.com.cn
Objective:
To observe the effect on the inhibition of coronary atherosclerosis hardening of the paraoxonase gene (PON-1) which transfected to the rabbit epicardial adipose tissue.
Methods:
Rabbit coronary atherosclerosis model was established by high-fat feeding, liposome-encapsulated recombinant plasmid pEGFP-PON-1 50 μ L was injected to the rabbit pericardial cavity, and was harvested 4 weeks after transfection.
Results:
The epicardial fat transfected PON-1 gene had effect on the high lipid level. It significantly increased expression of PON-1 in peripheral arterial vascular tissue (P <0.05); and significantly reduced total cholesterol and low-density lipoprotein cholesterol levels (P<0.05), and the thickness ratio of coronary artery intima/media (P <0.05).
Conclusions:
The injection of the PON-1 gene in the pericardial cavity can effectively suppress the formation of coronary atherosclerosis.
