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Related Experiment Videos

Allergic nephropathy associated with ciprofloxacin.

S Rastogi1, J L Atkinson, J T McCarthy

  • 1Division of Nephrology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Mayo Clinic Proceedings
|July 1, 1990
PubMed
Summary

Ciprofloxacin can cause allergic tubulointerstitial nephritis, a rare kidney condition. Prompt treatment with drug withdrawal and corticosteroids led to patient recovery.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Immunology

Background:

  • Antibiotic-associated kidney injury is a significant clinical concern.
  • Fluoroquinolones, including ciprofloxacin, are widely prescribed antibiotics.
  • Allergic interstitial nephritis is a known, albeit uncommon, adverse drug reaction.

Observation:

  • A patient presented with nonoliguric renal failure.
  • Laboratory findings included peripheral eosinophilia and eosinophiluria.
  • These symptoms suggested an allergic reaction to a medication.

Findings:

  • The patient's condition was diagnosed as ciprofloxacin-related allergic tubulointerstitial nephritis.
  • Renal function improved after discontinuing ciprofloxacin.
  • A short course of oral corticosteroids further aided recovery.

Implications:

  • Ciprofloxacin should be considered as a potential cause of acute kidney injury presenting with allergic signs.
  • Clinicians must maintain a high index of suspicion for drug-induced tubulointerstitial nephritis.
  • Early recognition and management are crucial for favorable outcomes in antibiotic-induced kidney disease.

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