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Lorazepam as a premedication.

G Gale, S Galloon

Canadian Anaesthetists' Society Journal

|January 1, 1976

Summary

This summary is machine-generated.

Lorazepam significantly reduced anxiety and improved amnesia compared to pantopon in women undergoing uterine procedures. While lorazepam offered better outcomes, it required more anesthesia, unlike pantopon which caused more side effects.

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Area of Science:

Anesthesiology
Pharmacology

Background:

Premedication is crucial for managing patient anxiety and ensuring procedural comfort.
Intramuscular lorazepam and pantopon are potential options for pre-anesthetic medication.

Purpose of the Study:

To compare the efficacy of intramuscular lorazepam versus pantopon as premedication in healthy women undergoing dilation and curettage (D&C).

Main Methods:

A double-blind, randomized study design.
Assessment of anxiety via patient self-rating and observer evaluation.
Evaluation of sedation, amnesia, and post-operative side effects including nausea, vomiting, and headache.

Main Results:

Lorazepam demonstrated a significantly greater reduction in anxiety and a higher incidence of amnesia compared to pantopon.

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Sedation levels were comparable between the two drugs.

Pantopon was associated with more nausea, vomiting, and headaches, while lorazepam required higher thiopentone doses and potentially longer recovery times.

Conclusions:

Lorazepam is a highly effective premedication, superior to pantopon in reducing anxiety and amnesia with fewer gastrointestinal side effects.
The lack of analgesia with lorazepam necessitates increased intraoperative anesthesia, a key consideration for its use.