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Updated: May 10, 2026
09:18
Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
Crosstalk between apoptosis, necrosis and autophagy
Vassiliki Nikoletopoulou1, Maria Markaki1, Konstantinos Palikaras1
1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.
Biochimica Et Biophysica Acta
|June 18, 2013
Summary
Cell death involves apoptosis and necrosis, which were once thought separate but now known to interact. Autophagy also plays a dual role, influencing both cell death types in development and disease.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Apoptosis and necrosis are primary cell death mechanisms.
- Previously considered distinct, they exhibit complex interplay in certain cellular contexts.
- Autophagy, typically survival-promoting, can also mediate cell death.
Purpose of the Study:
- To review recent literature on the crosstalk between apoptosis, necrosis, and autophagy.
- To highlight the significance of this interplay in normal development and disease.
- To elucidate the molecular mediators and signaling pathways involved in cell death decisions.
Main Methods:
- Literature review of recent findings on cell death pathways.
- Analysis of molecular mechanisms, signaling pathways, and subcellular sites.
- Focus on the interplay between apoptosis, necrosis, and autophagy.
Main Results:
- Apoptosis and necrosis are not mutually exclusive and can be balanced.
- Common molecular modules and switch-like mechanisms regulate cell death routes.
- Autophagy exhibits context-dependent pro-survival or pro-death functions.
Conclusions:
- The intricate crosstalk between apoptosis, necrosis, and autophagy is crucial.
- This interplay significantly impacts normal development and various pathologies.
- Understanding these cell death pathways offers insights into disease mechanisms.
Keywords:
AIFAMPKAPAF1Adenosine Monophosphate activated KinaseApoptosisApoptosis Inducing FactorApoptotic Protease Activating Factor 1AutophagyB-cell lymphoma 2B-cell lymphoma extra largeBCL-2BCL-X(l)BEC1BHBcl-2 homologyBeclin-1Cell deathDAPKDRAMDamage-Regulated Autophagy ModulatorFADDFAS Associated Death DomainFLICEFLICE-Like Inhibitory ProteinFLIPFOXO1Forkhead Box Protein O1HDGFHMGB1Hepatoma Derived Growth FactorHigh Mobility Group protein B1IGF1IL1βInsulin Growth Factor 1LKB1Liver Kinase B1MEFsMNNGMOMPMitoptosisN-methyl-N0-nitrosoguanidineNEMONF-kBNF-kB essential modulatorNLRP3NOD-like receptor family pyrin domain containing 3NecroptosisNecrosisNuclear factor kappa-light-chain-enhancer of activated B cellsPAMPPARP1PCDPI3KPRRPTPPUMAPathogen Associated Molecular PatternsPhosphatidyl Inositol 3 KinasePoly(ADP ribose) Polymerase 1RIP1RIP3Receptor Interacting Protein 1Receptor Interacting Protein 3SIRT2Sirtuin 2TNF related apoptosis inducing ligandTNFR Associated Death DomainTNFR Associated Factor 2TNFR Associated Factor 5TNFR1TNFR2TNFαTNFα Receptor 1TNFα receptor 2TRADDTRAF2TRAF5TRAILTRAIL Receptor 1TRAIL Receptor 2TRAILR1TRAILR2Tumor Necrosis Factor alphacIAP1cIAP2caspase 8cellular inhibitor of apoptosis 1cellular inhibitor of apoptosis 2death associated protein kinaseinterleukin 1βmTORmammalian target of rapamycinmitochondrial outer membrane permeabilizationmouse embryonic fibroblastsp53-Upregulated Modulator of Apoptosispathogen recognition receptorpermeability transition poreprogrammed cell deathtAIFtruncated Apoptosis Inducing Factor
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