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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
The CD14--159C/T polymorphisms and the risks of tuberculosis: a meta-analysis
Fang-Fang Guo1, Qing Xie, Ru-Feng An
1Department of Pharmacy, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan City, Shandong Province 250012, China.
Summary
This meta-analysis found a link between the CD14--159C/T polymorphism and tuberculosis risk in Asians. No significant association was observed in Caucasians, highlighting ethnic differences in genetic susceptibility to TB.
Area of Science:
- Genetics
- Immunology
- Epidemiology
Background:
- Conflicting results exist regarding the association between CD14--159C/T polymorphisms and tuberculosis (TB) risk.
- A comprehensive meta-analysis is needed to clarify this relationship.
Purpose of the Study:
- To perform a meta-analysis to accurately estimate the association between CD14--159C/T polymorphism and TB risk.
- To investigate potential ethnic and TB type-specific differences in this association.
Main Methods:
- A systematic literature search and manual search were conducted to identify relevant studies.
- Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using fixed- or random-effects models.
- Eight studies with 1729 cases and 1803 controls were included in the meta-analysis.
Main Results:
- A significant association between CD14--159C/T polymorphism and TB risk was detected in the recessive model (TT vs. TC/CC, OR=1.48).
- Significant associations were observed in Asians (e.g., T vs. C, OR=1.49; TT vs. CC, OR=1.94).
- No significant association was found in Caucasians, and a borderline significant association was noted for pulmonary TB in subgroup analysis.
Conclusions:
- The CD14--159C/T polymorphism may be associated with TB risk in Asian populations.
- This association was not significant in Caucasians, suggesting ethnic-specific effects.
- Further large-scale, well-designed studies are required to validate these findings.
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