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Related Experiment Video

Updated: May 10, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Advanced lipoprotein measures and recurrent preterm birth.

John M Thorp¹, Madeline Murguia Rice, Margaret Harper

¹Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.

American Journal of Obstetrics and Gynecology

|June 18, 2013

Summary

Lipoprotein particle size, specifically very low-density lipoprotein (VLDL), may influence preterm birth (PTB) risk. Further research into VLDLNMR particle size could inform interventions for preventing PTB.

Keywords:

birth lipids nutrition

Related Experiment Videos

Last Updated: May 10, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

Cardiovascular Science
Reproductive Science
Metabolic Science

Background:

Lipoproteins are implicated in atherogenic and inflammatory pathways.
These processes may contribute to adverse pregnancy outcomes, including preterm birth (PTB).

Purpose of the Study:

To investigate the association between lipoprotein particle size and concentration and the risk of PTB.
To determine if lipoprotein variations are linked to PTB occurring before 35 weeks' gestation.

Main Methods:

A case-control study analyzed plasma samples from 128 PTB cases and 132 term controls.
Nuclear magnetic resonance (NMR) spectroscopy characterized 17 lipoprotein particles.
Logistic regression models controlled for relevant covariates.

Main Results:

Only one lipoprotein particle size, very low-density lipoprotein (VLDL) NMR particle size, showed a significant association with PTB.
Increased VLDLNMR particle size correlated with a higher odds of PTB.

Conclusions:

Midpregnancy lipoprotein variations were not broadly associated with recurrent PTB in women with a history of PTB.
The observed association with VLDLNMR particle size suggests potential targets for lifestyle, nutritional, or pharmacologic interventions to prevent PTB.