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Repeatability of ocular response analyzer metrics: a gender-based study.

Vinoo Philip David¹, Richard E Stead, Stephen A Vernon

¹Department of Ophthalmology, Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham, United Kingdom.

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|June 18, 2013

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Repeatable corneal biomechanical measurements using the Ocular Response Analyzer (ORA) were confirmed in normal eyes. Intraocular pressure (IOP) and corneal hysteresis (CH) showed excellent repeatability, with no significant sex-based differences.

Area of Science:

Ophthalmology
Biomechanical Engineering
Optometry

Background:

Intraocular pressure (IOP) measurement is crucial for glaucoma diagnosis and management.
Corneal biomechanics significantly influence IOP readings, necessitating accurate assessment.
The Ocular Response Analyzer (ORA) provides advanced corneal biomechanical parameters.

Purpose of the Study:

To evaluate the repeatability of Goldmann-correlated IOP (IOPG), corneal-compensated IOP (IOPCC), corneal hysteresis (CH), and corneal resistance factor (CRF) using the ORA.
To determine if corneal biomechanical parameters or their repeatability differ between sexes.

Main Methods:

Prospective observational study involving 100 healthy adults (50 men, 50 women).
ORA parameters were measured in both eyes across three sets of four consecutive readings within 30 minutes by a single examiner.

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Intraclass correlation coefficient (ICC) and coefficient of repeatability (CR) were calculated.

Main Results:

Excellent repeatability (ICC > 0.9) was observed for IOPG, IOPCC, and CH in both sexes.
CRF showed excellent repeatability (ICC > 0.9) in men and good repeatability (ICC = 0.86) in women.
The ORA's coefficient of repeatability met British Standards Institution criteria.
No significant differences in corneal biomechanical factors or IOP were found between men and women.

Conclusions:

Corneal biomechanical parameters measured by the ORA demonstrate high repeatability in normal eyes.
The ORA is a reliable tool for assessing corneal biomechanics and IOP.
No significant sex-based differences were detected in these corneal biomechanical measurements.