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[The antilysozyme activity of yeasts in the genus Candida]
Abstract:
The fungi of the genus Candida isolated from patients with oral mucosa candidiasis and from candidiasis carriers have been studied for their antilysozyme activity. These fungi (Candida albicans, C. tropicalis, C. krusei, C. quilliermondii) are antilysozyme-active. A high antilysozyme activity of the fungi isolated from patients with oral mucosa candidiasis permits supposing that the presence of this trait may be one of the factors of microorganism pathogenicity. The effective antimycotic therapy (clotrimasole, sanguirhitrin) decreases the antilysozyme activity of fungi of the genus Candida.
Insights
Fungi causing oral candidiasis, including Candida albicans, show high antilysozyme activity, potentially increasing pathogenicity. Effective antifungal treatments reduce this activity.
Area of Science:
- Medical Mycology
- Immunology
- Infectious Diseases
Background:
- Oral candidiasis is a common fungal infection.
- The genus Candida includes several opportunistic pathogens.
- Lysozyme plays a role in innate immunity against microbial infections.
Purpose of the Study:
- To investigate the antilysozyme activity of Candida species isolated from oral candidiasis patients and carriers.
- To determine if antilysozyme activity correlates with pathogenicity.
- To assess the impact of antifungal therapy on Candida antilysozyme activity.
Main Methods:
- Isolation and identification of Candida species (Candida albicans, C. tropicalis, C. krusei, C. quilliermondii).
- Assay of antilysozyme activity in fungal isolates.
- Evaluation of antilysozyme activity before and after antimycotic therapy (clotrimazole, sanguirhitrin).
Main Results:
- All studied Candida species exhibited antilysozyme activity.
- Isolates from patients with oral candidiasis demonstrated higher antilysozyme activity compared to carriers.
- Antimycotic therapy significantly reduced the antilysozyme activity of Candida isolates.
Conclusions:
- Antilysozyme activity is a characteristic of pathogenic Candida species.
- This trait may contribute to the virulence of Candida in oral infections.
- Antifungal treatments effectively diminish the antilysozyme capacity of Candida.