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Updated: May 10, 2026

05:46
Fluorescence-Based Detection of FEN1 Nuclease Activity and Screening of Small-Molecule Inhibitors
Published on: June 27, 2025
A superquenched DNAzyme-perylene complex: a convenient, universal and low-background strategy for fluorescence
Ting Fu1, Xu-Hua Zhao, Hua-Rong Bai
1Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Abstract:
Taking advantage of the super-quenching effect of the cationic perylene derivative on adjacent fluorophores, we for the first time reported a DNAzyme-perylene complex-based strategy for constructing fluorescence catalytic biosensors with improved sensitivity.
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