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Updated: May 10, 2026
06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Primary adrenal lymphoma: a systematic review.
Armin Rashidi1, Stephen I Fisher
1Department of Internal Medicine, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 410, Norfolk, VA, 23507, USA, rashida@evms.edu.
Annals of Hematology
|June 18, 2013
Summary
Primary adrenal lymphoma (PAL) is a rare, aggressive cancer primarily affecting elderly males. Treatment with chemotherapy, especially rituximab-containing regimens, has improved prognosis, with adrenal insufficiency being a key predictor.
Area of Science:
- Oncology
- Hematology
- Radiology
Background:
- Primary adrenal lymphoma (PAL) is an exceptionally rare malignancy, with fewer than 200 cases reported globally.
- Characterized by aggressive behavior and specific imaging features, PAL presents diagnostic and therapeutic challenges.
Purpose of the Study:
- To systematically review and synthesize existing literature on primary adrenal lymphoma.
- To elucidate the clinical characteristics, diagnostic features, and prognostic factors of PAL.
Main Methods:
- Comprehensive literature search of all reported primary adrenal lymphoma cases up to June 2013.
- Systematic review and analysis of 187 reported cases.
Main Results:
- PAL typically presents as large, bilateral adrenal masses in elderly males, often with adrenal insufficiency and B-symptoms.
- Common subtypes include diffuse large B-cell lymphoma (78%) and peripheral T-cell lymphoma (7%).
- Metabolic hyperactivity, hypovascularity, and hypoechogenicity on ultrasound are characteristic findings.
Conclusions:
- Prognosis for PAL has improved with rituximab-based chemotherapy.
- Chemotherapy administration and adrenal insufficiency are significant independent predictors of patient outcome.
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