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Integrating zebrafish toxicology and nanoscience for safer product development
1Department of Environmental and Molecular Toxicology, the Environmental Health Sciences Center, Oregon State University, Corvallis, OR ; Safer Nanomaterials Nanomanufacturing Initiative, Oregon Nanoscience and Microtechnologies Institute, Eugene, OR, USA.
Green Chemistry : an International Journal and Green Chemistry Resource : GC
|June 18, 2013
Summary
Developing safer engineered nanomaterials (ENMs) requires rapid hazard identification. Zebrafish toxicology models offer a high-throughput, cost-effective solution for predicting nanochemistries
Area of Science:
- Green Chemistry and Nanotoxicology
- Environmental Science and Health
Background:
- The development of safer products and manufacturing processes is a key goal, increasingly guided by Green Chemistry principles.
- Engineered nanomaterials (ENMs) present unique challenges, necessitating rapid identification of potentially hazardous nanochemistries.
- A predictive toxicology paradigm is crucial for advancing nanoscience responsibly.
Purpose of the Study:
- To highlight the need for a nanotoxicology paradigm that can quickly identify hazardous nanochemistries.
- To explore the utility of predictive toxicological modeling in developing zebrafish for high-throughput hazard assessment of ENMs.
- To advocate for the early integration of zebrafish models into the ENM discovery pipeline.
Main Methods:
- Review of advances in predictive toxicological modeling using developing zebrafish.
- Assessment of zebrafish as a high-throughput, cost-effective vertebrate model for nanotoxicity.
- Evaluation of the potential for early pipeline detection of human and environmental health impacts.
Main Results:
- Predictive toxicological modeling in zebrafish offers a practical, high-throughput approach for hazard identification.
- Zebrafish provide a vertebrate model for hazard prediction that is a low-cost alternative to rodents.
- Early application of zebrafish models can significantly enhance the development of safer ENMs.
Conclusions:
- Zebrafish toxicology models represent a promising avenue for establishing a rapid and efficient nanotoxicology paradigm.
- Integrating zebrafish testing early in the ENM discovery pipeline can accelerate the creation of greener and safer nanoscience.
- This approach facilitates informed decision-making in the design and production of safer commercial ENMs, benefiting human and environmental health.
