Related Experiment Video
Updated: May 10, 2026
04:48
A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
NMDA Receptor Activity in Neuropsychiatric Disorders
Shaheen E Lakhan1, Mario Caro, Norell Hadzimichalis
1Biosciences Department, Global Neuroscience Initiative Foundation , Beverly Hills, CA , USA ; Neurological Institute, Cleveland Clinic , Cleveland, OH , USA.
Frontiers in Psychiatry
|June 18, 2013
Summary
Disruptions in N-Methyl-d-aspartate (NMDA) receptor signaling are linked to various neuropsychiatric disorders. Targeting this pathway may offer a viable option for managing overlapping psychotic symptoms across these conditions.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- N-Methyl-d-aspartate (NMDA) receptors are crucial for physiological functions and cellular homeostasis.
- Dysregulation of NMDA receptor activity is implicated in numerous neuropsychiatric disorders, including schizophrenia, mood disorders, and neurodegenerative diseases.
Purpose of the Study:
- To explore the NMDA receptor pathway as a potential unifying link for overlapping psychotic symptoms in diverse neuropsychiatric conditions.
- To provide an overview of neuropsychiatric disorders associated with altered NMDA receptor activity.
Main Methods:
- Literature review and synthesis of existing research on NMDA receptor function in neuropsychiatric disorders.
- Analysis of the commonalities in NMDA receptor pathway alterations across different pathologies.
Main Results:
- Alterations in NMDA receptor activity are a prominent feature across a spectrum of neuropsychiatric disorders.
- The NMDA receptor pathway's involvement suggests a shared biochemical basis for psychotic symptoms.
Conclusions:
- The NMDA receptor pathway represents a significant therapeutic target for managing shared psychotic symptoms.
- Continued pharmaceutical intervention focused on the NMDA receptor pathway may offer effective symptom management strategies.
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