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Immunohaematological reference values for HIV-negative healthy adults in Botswana
Madisa Mine1, Sikhulile Moyo, Penny Stevens
1National Health Laboratory, Gaborone, Botswana ; Botswana-Harvard AIDS Institute Partnership (BHP), Princess Marina Hospital, Gaborone, Botswana.
African Journal of Laboratory Medicine
|June 18, 2013
Summary
This study established new immunohaematological reference intervals for healthy adults in Botswana. These local values are crucial for accurate patient diagnosis and clinical trial management.
Area of Science:
- Immunohaematology
- Clinical Laboratory Science
- Public Health
Background:
- Clinical laboratories in Botswana traditionally relied on external reference intervals for immunohaematological values.
- Lack of local reference data may impact diagnostic accuracy and clinical trial validity.
Purpose of the Study:
- To determine reference intervals for normal immunohaematological values in a healthy adult population in Botswana.
- Establish local means, medians, and 2.5th/97.5th percentiles for key laboratory parameters.
Main Methods:
- A cross-sectional study involving 261 healthy adults (126 males, 135 females) in southern Botswana.
- Measurement of immunological and haematological parameters using standardized laboratory techniques.
Main Results:
- Established reference intervals for immunohaematological parameters in healthy Botswana adults.
- Mean hemoglobin levels were significantly lower in women (12.4 g/dL) compared to men (15.1 g/dL).
- Women's hemoglobin reference values (9.0-15.0 g/dL) align with regional, but differ from predominantly White population standards.
Conclusions:
- The determined reference intervals serve as a vital tool for patient management in Botswana.
- Local reference values can inform clinical trial participant selection and adverse event monitoring.
- This study contributes essential data for improving healthcare and research in the region.
