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[Treatment of superficial infantile hemangiomas with topical propranolol]

Jing-Ning Niu1, Guang-Qi Xu, Ren-Rong Lü

  • 1Department of Aesthetic, Plastic, and Burn Surgery, Shandong Provincial Hospital, Jinan 250021, China.

Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery
|June 19, 2013
PubMed

Insights

Topical 1% propranolol ointment effectively treated superficial infantile hemangiomas (IHs) in 87.8% of cases with no systemic side effects. This offers a safe treatment option for IHs.

Area of Science:

  • Dermatology
  • Pediatrics
  • Pharmacology

Context:

  • Infantile hemangiomas (IHs) are common benign vascular tumors in infants.
  • Superficial IHs can cause cosmetic concerns and potential complications.
  • Current treatment options have limitations, necessitating exploration of new therapeutic strategies.

Purpose:

  • To assess the efficacy and safety of 1% propranolol ointment for superficial infantile hemangiomas.
  • To evaluate treatment response based on changes in size, texture, and color.
  • To identify any adverse effects associated with topical propranolol therapy.

Summary:

  • A retrospective review of 49 children with 58 superficial IHs treated with 1% propranolol ointment.
  • Treatment involved thrice-daily application for a mean of 21.1 weeks.
  • Good or partial response was observed in 87.8% of cases, with no systemic complications.

Impact:

  • 1% propranolol ointment demonstrates significant efficacy in treating superficial IHs.
  • Topical propranolol is a safe adjuvant therapy during the 'wait-and-see' period for IHs.
  • This treatment offers a promising, non-invasive approach for managing infantile hemangiomas.
Abstract

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