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Related Concept Videos

ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and are...
Primary Active Transport01:29

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would not...
Primary Active Transport01:47

Primary Active Transport

In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Fabrication of a Solution-gated Indium-Tin-Oxide-based One-piece Transistor Enabling Sensitive Biosensing
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Published on: August 29, 2025

Bioinspired artificial single ion pump.

Huacheng Zhang1, Xu Hou, Lu Zeng

  • 1Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.

Journal of the American Chemical Society
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel bioinspired ion pump using a pH-responsive double-gate nanochannel. This artificial system mimics biological ion pumps, enabling intelligent ion transport control for advanced applications.

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Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research

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Area of Science:

  • Nanotechnology and Materials Science
  • Bioinspired Engineering
  • Physical Chemistry

Background:

  • Artificial functional nanochannels offer potential in nanofluidics, energy conversion, and biosensors.
  • Replicating intelligent ion transport control, akin to biological ion pumps, remains a significant challenge.
  • Existing artificial ion channels primarily exhibit passive transport properties.

Purpose of the Study:

  • To design and demonstrate a bioinspired artificial ion pump with intelligent ion transport control.
  • To achieve active ion pumping features comparable to biological ion pumps using a novel nanochannel design.
  • To explore applications in smart nanofluidic devices and energy conversion.

Main Methods:

  • Fabrication of a unique bioinspired single ion pump utilizing a cooperative pH response double-gate nanochannel.
  • Stimulation of the nanochannel using symmetric and asymmetric pH environments to control gate behavior.
  • Analysis of ionic transport features under varying pH conditions and concentration gradients.

Main Results:

  • Demonstrated an alternating gates ion pumping process under symmetric pH stimuli.
  • Achieved transformation of the ion pump into an ion channel under asymmetric pH stimuli.
  • Exhibited a fail-safe ion pumping feature under combined pH stimuli, with processes reproducible under concentration gradients.

Conclusions:

  • The developed bioinspired ion pump successfully replicates key ionic transport features of biological ion pumps.
  • The cooperative pH response double-gate nanochannel offers intelligent control over molecular and ionic transport.
  • This technology holds promise for active transportation-controlling nanofluidic devices, energy conversion, and desalination.