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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: May 10, 2026

Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics
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Published on: September 14, 2015

Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain.

June-Hee Park1, Zachary Glass, Kasim Sayed

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

The European Journal of Neuroscience
|June 19, 2013
PubMed
Summary
This summary is machine-generated.

Calorie restriction (CR) boosts neural stem cell division in aging female mice brains. This increased cell proliferation did not significantly enhance new neuron formation, suggesting CR may promote stem cell activity.

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06:52

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats

Published on: February 9, 2024

Area of Science:

  • Neuroscience
  • Aging Research
  • Stem Cell Biology

Background:

  • Neurogenesis, the production of new neurons, is vital for cognitive function.
  • Reduced neurogenesis in aging brains may lead to cognitive decline.
  • Calorie restriction (CR) and rapamycin extend lifespan and delay age-related functional decline.

Purpose of the Study:

  • To investigate the effects of prolonged calorie restriction (CR) or rapamycin on hippocampal neural stem and progenitor cell proliferation in aging mice.
  • To determine if CR or rapamycin influences the number of dividing neural stem and progenitor cells in the aging brain.

Main Methods:

  • Utilized a reporter mouse line where neural stem and progenitor cells express green fluorescent protein (GFP).
  • Administered prolonged calorie restriction (CR) or rapamycin to aging mice.
  • Examined cell proliferation in the dentate gyrus of the hippocampus.

Main Results:

  • Calorie restriction (CR) significantly increased the number of dividing cells in the dentate gyrus of female mice.
  • The majority of these proliferating cells were identified as nestin-GFP-expressing neural stem or progenitor cells.
  • Despite increased stem and progenitor cell division, there was no significant rise in doublecortin-positive newborn neurons.

Conclusions:

  • Calorie restriction (CR) increases the proliferation of neural stem and progenitor cells in the aging female brain.
  • This enhanced proliferation does not necessarily translate to a significant increase in new neuron formation.
  • Findings suggest CR may modulate neural stem cell division dynamics in aging females.