Related Experiment Video
Updated: May 10, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
Maintaining skin integrity in the aged: a systematic review
J Kottner1, A Lichterfeld, U Blume-Peytavi
1Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Basic skin care for aging skin, including gentle cleansers and moisturizers with humectants or occlusives, can improve skin dryness and integrity. However, the evidence base remains weak due to methodological limitations.
Area of Science:
- Dermatology
- Gerontology
- Nursing
Background:
- Aging skin undergoes structural and functional changes, increasing vulnerability.
- Maintaining skin integrity is crucial for the elderly population.
Purpose of the Study:
- To systematically review evidence on basic skin care interventions for maintaining skin integrity in the aged.
- To evaluate the efficacy and effectiveness of these interventions.
Main Methods:
- Systematic review of primary intervention studies (1990-2013) from multiple databases (Medline, EMBASE, CINAHL, Scopus, SCI).
- Inclusion criteria: studies on physiologically aged skin (≥50 years) using skin care products.
- Methodological quality assessment and evidence level assignment.
Main Results:
- 33 studies included, focusing on dry skin, incontinence-associated dermatitis, and ulcerations.
- Syndet/amphoteric surfactant cleansers improved dryness and protected skin compared to soap and water.
- Humectant moisturizers significantly improved skin dryness.
- Occlusive barrier products reduced skin injuries.
Conclusions:
- The current evidence base for basic skin care in the aged is weak due to methodological limitations.
- Low-irritating cleansers and moisturizers with humectants or occlusives are recommended for maintaining skin barrier function.
- Further research is needed on cleansing regimens and comparative moisturizer benefits.
Related Concept Videos
The Effect of Aging on Tissues
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Pharmacodynamics in Geriatric Patients: Effects of Age
Development of Human Microbiota