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Negative priming in amphetamine psychosis
Solmaz Asnafi1, Vandad Sharifi, Mehdi Tehranidoost
1Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran.
Psychiatry Research
|June 19, 2013
Summary
Amphetamine psychosis patients did not show deficits in attentional inhibition, measured by negative priming (NP). These findings suggest cognitive mechanisms for NP may be unaffected in drug-induced psychosis.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Amphetamine abuse can induce psychosis with symptoms resembling paranoid schizophrenia.
- Impaired attentional inhibition of irrelevant information is linked to psychotic symptoms in schizophrenia.
- The negative priming (NP) paradigm is used to assess attentional inhibition deficits.
Purpose of the Study:
- To investigate attentional inhibition in patients with amphetamine-induced psychosis using a spatial negative priming task.
- To compare the NP performance of patients with amphetamine-induced psychotic disorder to healthy controls.
- To explore the correlation between NP effects and the severity of psychotic symptoms.
Main Methods:
- A spatial negative priming (NP) task was administered to 19 patients with amphetamine-induced psychotic disorder and 20 healthy controls.
- The Brief Psychiatric Rating Scale (BPRS) was used to assess the severity of psychotic symptoms in patients before testing.
- Performance on the NP task was analyzed to identify deficits in attentional inhibition.
Main Results:
- Patients with amphetamine-induced psychosis did not exhibit significant deficits in negative priming (NP) compared to healthy subjects.
- The magnitude of the NP effect was comparable between the patient group and the control group.
- No significant correlation was found between the NP effect and the severity of psychotic symptoms as measured by the BPRS.
Conclusions:
- Attentional inhibition, as measured by the spatial NP task, may not be impaired in individuals with amphetamine-induced psychosis.
- The cognitive mechanisms underlying negative priming might be preserved in amphetamine psychosis.
- Further research is needed to fully understand the cognitive profile of amphetamine-induced psychosis.
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