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Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
Published on: November 5, 2014
Physiology of ADP-ribosylation
Friedrich Koch-Nolte1, Mathias Ziegler
1University Medical Center Hamburg, Hamburg, Germany.
Abstract:
ADP-ribosylation of proteins is a versatile post-translational modification that can alter the chemistry of a specific side chain or provide a handle for the binding of a recognition domain. A better understanding of ADP-ribosylating enzymes and their targets is opening new therapeutic opportunities. This minireview series focuses on physiological aspects of ADP-ribosylation, while a companion series focuses on drug targets.
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