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[Long-term follow up of children with orthostatic proteinuria]
1Budai Gyermekkórház-Rendelöintézet, Semmelweis Orvostudományi Egyetem, I. sz. Gyermekklinika, Budapest.
Insights
This study followed 18 children with orthostatic proteinuria for 4.5 years, finding renal functions remained good. Changes in proteinuria quantity and quality over time are key prognostic indicators.
Area of Science:
- Pediatric Nephrology
- Clinical Medicine
- Human Physiology
Context:
- Orthostatic proteinuria affects children, characterized by protein excretion in urine when upright.
- Understanding long-term outcomes and prognostic factors is crucial for managing this condition.
- Previous studies have focused on short-term observations, necessitating longer follow-up evaluations.
Purpose:
- To evaluate long-term renal function and clinical parameters in children with orthostatic proteinuria.
- To investigate the influence of ptosis renis (kidney droop) on orthostatic proteinuria.
- To identify prognostic indicators for children diagnosed with orthostatic proteinuria.
Summary:
- 18 children with orthostatic proteinuria were followed for an average of 4.5 years.
- Evaluated parameters included body measures, renal function, blood pressure, pulse rate, ECG, kidney position (ptosis renis), and proteinuria characteristics (quantity and molecular weight) day and night.
- While patients were taller with lower body mass index, renal functions remained good; ptosis renis was observed in 11 patients. Changes in proteinuria quantity and quality were noted over time, while other parameters remained stable or similar to controls.
Impact:
- Identifies changes in proteinuria quantity and quality as significant prognostic factors in pediatric orthostatic proteinuria.
- Provides valuable long-term follow-up data for a cohort of children with this condition.
- Highlights the importance of monitoring proteinuria characteristics for predicting patient outcomes.
Abstract:
The authors summarize their observations of 18 children with orthostatic proteinuria. The average time of follow-up was 4 and half years. They examined body measures and renal functions of the patients and compared their blood pressure, pulse rate, electrocardiographic curve, morphological and positional conditions of kidneys in lying and standing position, as well as change of quantity and quality of proteinuria (high, middle and low molecular weight) at day time and night both in proteinuric children with and without ptosis renis and in controls. The patients were taller than the average, but their body mass was small compared to their weight. Ptosis renis was found in 11 patients. Renal functions remained good. The authors detected changes only in quantity and quality of proteinuria during of long term follow-up, the other parameters remained normal or the change was like that of the controls. They propose, that these two parameters are of prognostic importance.