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Published on: May 16, 2025
Potential food-drug interactions in patients with rheumatoid arthritis
Kayo Masuko1, Shigeto Tohma, Toshihiro Matsui
1Graduate School of Nutritional Science, Sagami Women's University, Kanagawa, Japan. k_msk@mac.com
Abstract:
Various medications are used for the treatment of rheumatoid arthritis (RA). Food-drug interactions may occur with concomitant ingestion of particular food. For example, methotrexate (MTX), the anchor drug in the therapeutic strategy against RA, is an antifolate agent. Excessive presence or absence of dietary folic acid may regulate MTX metabolism, possibly leading to unexpected adverse reactions. In this review, we focus on MTX, isoniazide and calcineurin inhibitors, and the implications of potential food-drug reactions in rheumatology, suggesting the important role of nutritional evaluations in RA patients.
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